New Tissue Formation: Migration of Fibroblasts
To produce new tissue, fibroblasts proliferate in the wound and migrate with the help of the growth factors and a very important glycoprotein called fibronectin. Fibronectin acts as a conduit for fibroblasts. It binds to both the wound matrix and the fibroblast, allowing the fibroblast to march down it (the fibronectin), move along the chemotactic gradient of growth factors, and take up residence in the wound.

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